Showing posts with label SleepScience. Show all posts
Showing posts with label SleepScience. Show all posts

Monday, October 19, 2026

Genetic Factors Linked To Nightmares and Poor Mental Health Show Substantial Overlap

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Agenotyping study involving tens of thousands of individuals in Finland identified a significant overlap between genetic factors linked to nightmares and those associated with anxiety, depression, posttraumatic stress disorder, and neuroticism. The study also found that individuals with insomnia were more likely to experience frequent nightmares. The research was published in Translational Psychiatry.Nightmares are vivid and unsettling dreams that typically result in feelings of fear, distress, or anxiety upon awakening…..….Story continues…

By: Vladimir Hedrih

Source: psypost

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Critics:

Scientific research shows that nightmares may have many causes. In a study focusing on children, researchers were able to conclude that nightmares directly correlate with the stress in children’s lives. Children who experienced the death of a family member or a close friend or know someone with a chronic illness have more frequent nightmares than those who are only faced with stress from school or stress from social aspects of daily life.

A study researching the causes of nightmares focuses on patients who have sleep apnea. The study was conducted to determine whether or not nightmares may be caused by sleep apnea, or being unable to breathe. In the nineteenth century, authors believed that nightmares were caused by not having enough oxygen, therefore it was believed that those with sleep apnea had more frequent nightmares than those without it.

The results actually showed that healthy people have more nightmares than sleep apnea patients. Another study supports the hypothesis. In this study, 48 patients (aged 20–85 yrs) with obstructive airways disease (OAD), including 21 with and 27 without asthma, were compared with 149 sex- and age-matched controls without respiratory disease. OAD subjects with asthma reported approximately 3 times as many nightmares as controls or OAD subjects without asthma.

The evolutionary purpose of nightmares then could be a mechanism to awaken a person who is in danger. Lucid-dreaming advocate Stephen LaBerge has outlined a possible reason for how dreams are formulated and why nightmares occur. To LaBerge, a dream starts with an individual thought or scene, such as walking down a dimly lit street.

Since dreams are not predetermined, the brain responds to the situation by either thinking a good thought or a bad thought, and the dream framework follows from there. If bad thoughts in a dream are more prominent than good thoughts, the dream may proceed to be a nightmare. There is a view, possibly featured in the story A Christmas Carol, that eating cheese before sleep can cause nightmares, but there is little scientific evidence for this.

A single, biased study conducted by the British Cheese Board in 2005 argued that consuming cheese could trigger more vivid dreams, but this study was not backed up with sufficient research, and contradicts existing studies which found that consuming dairy products is associated with better overall sleep quality. Severe nightmares are also likely to occur when a person has a fever; these nightmares are often referred to as fever dreams.

Recent research has shown that frequent nightmares may precede the development of neurodegenerative diseases, such as Parkinson’s disease and dementia. Sigmund Freud and Carl Jung seemed to have shared a belief that people frequently distressed by nightmares could be re-experiencing some stressful event from the past. Both perspectives on dreams suggest that therapy can provide relief from the dilemma of the nightmarish experience.

Those with nightmares experience abnormal sleep architecture. The impact of having a nightmare during the night has been found to be very similar to that of insomnia. This is thought to be caused by frequent nocturnal awakenings and fear of falling asleep. When awoken from REM sleep by a nightmare, the dreamer can usually recall the nightmare in detail. They may also awaken in a heightened state of distress, with an elevated heart rate or increased perspiration.

 Nightmare disorder symptoms include repeated awakenings from the major sleep period or naps with detailed recall of extended and extremely frightening dreams, usually involving threats to survival, security, or self-esteem. The awakenings generally occur during the second half of the sleep period.

According to the International Classification of Sleep Disorders-Third Edition (ICSD-3), the nightmare disorder, together with REM sleep behaviour disorder (RBD) and recurrent isolated sleep paralysis, form the REM-related parasomnias subcategory of the Parasomnias cluster. Nightmares may be idiopathic without any signs of psychopathology or associated with disorders like stress, anxiety, substance abuse, psychiatric illness or PTSD (>80% of PTSD patients report nightmares).

As regarding the dream content of the dreams they are usually imprinting negative emotions like sadness, fear or rage.[4] According to the clinical studies the content can include being chased, injury or death of others, falling, natural disasters or accidents. Typical dreams or recurrent dreams may also have some of these topics.

Halliday (1987) grouped treatment techniques into four classes. Direct nightmare interventions that combine compatible techniques from one or more of these classes may enhance overall treatment effectiveness:

  • Analytic and cathartic techniques
  • Storyline alteration procedures
  • Face-and-conquer approaches
  • Desensitization and related behavioral techniques

Recurring post-traumatic stress disorder (PTSD) nightmares in which traumas are re-experienced respond well to a technique called imagery rehearsal. This involves dreamers coming up with alternative, mastery outcomes to the nightmares, mentally rehearsing those outcomes while awake and then reminding themselves at bedtime that they wish these alternative outcomes should the nightmares recur.

Research has found that this technique not only reduces the occurrence of nightmares and insomnia but also improves other daytime PTSD symptoms.The most common variations of imagery rehearsal therapy (IRT) “relate to the number of sessions, duration of treatment, and the degree to which exposure therapy is included in the protocol”.

Wednesday, June 10, 2026

A Commonly Used Sleep Aid May Have a Dangerous Side Effect

Drazen Zigic/iStock/Getty Images Plus

Around 1 in 5 US adults are thought to struggle with sleep health, and for many of us, the search for rest eventually leads to medication. But new research suggests a commonly used sleep aid may come with alarming side effects. Quetiapine (sold as Seroquel) is an antipsychotic drug approved for conditions including schizophrenia and bipolar disorder, but studies have shown it can improve sleep quality, and it’s often prescribed at lower doses as an ‘off-label’ treatment for insomnia……..Continue reading…..

By David Nield

Source: Science Alert

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Critics:

A publication by L. Xie and colleagues in 2013 explored the efficiency of the glymphatic system during slow wave sleep and provided the first direct evidence that the clearance of interstitial waste products increases during the resting state. Using a combination of diffusion iontophoresis techniques pioneered by Nicholson and colleagues, in vivo 2-photon imaging, and electroencephalography to confirm the wake and sleep states.

Xia and Nedergaard demonstrated that the changes in efficiency of CSF–ISF exchange between the awake and sleeping brain were caused by expansion and contraction of the extracellular space, which increased by ~60% in the sleeping brain to promote clearance of interstitial wastes such as amyloid beta. On the basis of these findings, they hypothesized that the restorative properties of sleep may be linked to increased glymphatic clearance of metabolic waste products produced by neural activity in the awake brain.

Pathologically, neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease are all characterized by the progressive loss of neurons, cognitive decline, motor impairments, and sensory loss. Collectively these diseases fall within a broad category referred to as proteinopathies due to the common assemblage of misfolded or aggregated intracellular or extracellular proteins.

According to the prevailing amyloid hypothesis of Alzheimer’s disease, the aggregation of amyloid-beta (a peptide normally produced in and cleared from the healthy young brain) into extracellular plaques drives the neuronal loss and brain atrophy that is the hallmark of Alzheimer’s dementia. Although the full extent of the involvement of the glymphatic system in Alzheimer’s disease

Other neurodegenerative disorders remains unclear, researchers have demonstrated through experiments with genetically modified mice that the proper function of the glymphatic clearance system was necessary to remove soluble amyloid-beta from the brain interstitium. In mice that lack the AQP4 gene, amyloid-beta clearance is reduced by approximately 55 percent. The glymphatic system also may be impaired after acute brain injuries such as ischemic stroke, intracranial hemorrhage, or subarachnoid hemorrhage.

In 2014, a group of researchers from the French Institute of Health and Medical Research (INSERM) demonstrated by MRI that the glymphatic system was impaired after subarachnoid hemorrhage, because of the presence of coagulated blood in the paravascular spaces.

Injection of tissue plasminogen activator (a fibrinolytic drug) in the CSF improved glymphatic functioning. In a parallel study, they also demonstrated that the glymphatic system was impaired after ischemic stroke in the ischemic hemisphere, although the pathophysiological basis of this phenomenon remains unclear. Notably, recanalization of the occluded artery also reestablished the glymphatic flow.

Familial natural short sleep is a rare, genetic, typically inherited trait where an individual sleeps for fewer hours than average without suffering from daytime sleepiness or other consequences of sleep deprivation. This process is entirely natural in this kind of individual, and it is caused by certain genetic mutations. A person with this trait is known as a “natural short sleeper”. This condition is not to be confused with intentional sleep deprivation, which leaves symptoms such as irritability or temporarily impaired cognitive abilities in people who are predisposed to sleep a normal amount of time but not in people with FNSS.

This sleep type is not considered to be a genetic disorder nor are there any known harmful effects to overall health associated with it; therefore it is considered to be a genetic, benign trait. The genes DEC2, ADRB1, NPSR1 and GRM1 are implicated in enabling short sleep. The quality of sleep may be evaluated from an objective and a subjective point of view. Objective sleep quality refers to how difficult it is for a person to fall asleep and remain in a sleeping state, and how many times they wake up during a single night.

Poor sleep quality disrupts the cycle of transition between the different stages of sleep. Subjective sleep quality in turn refers to a sense of being rested and regenerated after awaking from sleep. A study by A. Harvey et al. (2002) found that insomniacs were more demanding in their evaluations of sleep quality than individuals who had no sleep problems. Homeostatic sleep propensity (the need for sleep as a function of the amount of time elapsed since the last adequate sleep episode) must be balanced against the circadian element for satisfactory sleep.
Along with corresponding messages from the circadian clock, this tells the body it needs to sleep. The timing is correct when the following two circadian markers occur after the middle of the sleep episode and before awakening: maximum concentration of the hormone melatonin, and minimum core body. Human sleep-needs vary by age and amongst individuals; sleep is considered to be adequate when there is no daytime sleepiness or dysfunction.
Moreover, self-reported sleep duration is only moderately correlated with actual sleep time as measured by actigraphy, and those affected with sleep state misperception may typically report having slept only four hours despite having slept a full eight hours. Researchers have found that sleeping 6–7 hours each night correlates with longevity and cardiac health in humans, though many underlying factors may be involved in the causality behind this relationship.

Sleep difficulties are furthermore associated with psychiatric disorders such as depression, alcoholism, and bipolar disorder. Up to 90 percent of adults with depression are found to have sleep difficulties. Dysregulation detected by EEG includes disturbances in sleep continuity, decreased delta sleep and altered REM patterns with regard to latency, distribution across the night and density of eye movements. 

Sleep duration can also vary according to season. Up to 90% of people report longer sleep duration in winter, which may lead to more pronounced seasonal affective disorder.

Early study reveals why sleeping pills may not supply the best-quality snooze Live Science 19:36 Wed, 08 Jan 

Co-sleeping with pet dogs — but not cats — linked to poorer sleep in study

Is Alabama 6-foot-6 QB a sleeping giant in quarterback battle? Touchdown Alabama Magazine 19:46 Mon, 27 Jan 

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