Wednesday, May 1, 2024

Muscle Discovery Has Huge Potential For Healthier Aging


FABIO CAMANDONA/GETTY

It’s no secret that our muscles begin to weaken as we age. But scientists are only just beginning to understand the mechanisms underlying these changes, and what our muscles can do to combat them. Our muscle mass decreases by approximately 3 to 8 percent per decade after the age of 30, increasing our risk of injury and immobility. But not all muscle ages in the same way.

In a new study, published in the journal Nature Aging, researchers from the Welcome Sanger Institute and Sun Yat-sen University in China have revealed the first comprehensive atlas of aging muscles in humans to better understand what causes this age-associated muscle decline and how we can stop it.

To create their atlas, the team analyzed human muscle samples from 17 individuals between the ages of 20 and 75. By comparing high resolution images and gene expression patterns, the team discovered that the genes involved in controlling our cellular protein factors became less active in the older muscle samples, impairing our ability to repair and regenerate muscle as we age….Story continues

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Hypoxia treatment and resistance training alters microRNA profiling in rats skeletal muscle Nature.com 13:39 Wed, 10 Apr 

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